Zinc finger and BTB domain-containing protein 17
Intermolecular
Cysteine 26 and cysteine 26
Intramolecular
Cysteine 504 and cysteine 507
Cysteine 420 and cysteine 423
Cysteine 560 and cysteine 563
Cysteine 448 and cysteine 451
Cysteine 476 and cysteine 479
Cysteine 364 and cysteine 367
Cysteine 616 and cysteine 619
Cysteine 336 and cysteine 339
Cysteine 588 and cysteine 591
More...Cysteine 532 and cysteine 535
Cysteine 719 and cysteine 722
Cysteine 392 and cysteine 395
Cysteine 336 and cysteine 349
Cysteine 530 and cysteine 532
Cysteine 339 and cysteine 349
Cysteine 364 and cysteine 395
Cysteine 24 and cysteine 26
2q81 A 26 D 26
A redox-regulated disulphide may form between two units of Zinc finger and BTB domain-containing protein 17 at cysteines 26 and 26. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
2q81
Structure name
crystal structure of the miz-1 btb/poz domain
Structure deposition date
2007-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
14
% buried
100
Peptide A name
Zinc finger and BTB domain-containing protein 17
Peptide B name
Zinc finger and BTB domain-containing protein 17
Peptide A accession
Q13105
Peptide B accession
Q13105
Peptide A residue number
26
Peptide B residue number
26
Ligandability
2lvr A 6 A 9
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 504 and 507 (6 and 9 respectively in this structure).
Details
Redox score ?
88
PDB code
2lvr
Structure name
solution structure of miz-1 zinc finger 8
Structure deposition date
2012-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
Q13105
Residue number A
504
Residue number B
507
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 504 of Zinc finger and BTB domain-containing protein 17
Cysteine 507 of Zinc finger and BTB domain-containing protein 17
2m0d A 6 A 9
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 420 and 423 (6 and 9 respectively in this structure).
Details
Redox score ?
88
PDB code
2m0d
Structure name
solution structure of miz-1 zinc finger 5
Structure deposition date
2012-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
7
% buried
0
Peptide accession
Q13105
Residue number A
420
Residue number B
423
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 420 of Zinc finger and BTB domain-containing protein 17
Cysteine 423 of Zinc finger and BTB domain-containing protein 17
2lvu A 62 A 65
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 560 and 563 (62 and 65 respectively in this structure).
Details
Redox score ?
87
PDB code
2lvu
Structure name
solution structure of miz-1 zinc finger 10
Structure deposition date
2012-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
Q13105
Residue number A
560
Residue number B
563
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 560 of Zinc finger and BTB domain-containing protein 17
Cysteine 563 of Zinc finger and BTB domain-containing protein 17
2m0e A 34 A 37
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 448 and 451 (34 and 37 respectively in this structure).
Details
Redox score ?
87
PDB code
2m0e
Structure name
solution structure of miz-1 zinc finger 6
Structure deposition date
2012-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
448
Residue number B
451
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 448 of Zinc finger and BTB domain-containing protein 17
Cysteine 451 of Zinc finger and BTB domain-containing protein 17
2m0f A 62 A 65
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 476 and 479 (62 and 65 respectively in this structure).
Details
Redox score ?
86
PDB code
2m0f
Structure name
solution structure of miz-1 zinc finger 7
Structure deposition date
2012-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
476
Residue number B
479
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 476 of Zinc finger and BTB domain-containing protein 17
Cysteine 479 of Zinc finger and BTB domain-containing protein 17
2n26 A 62 A 65
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 364 and 367 (62 and 65 respectively in this structure).
Details
Redox score ?
85
PDB code
2n26
Structure name
solution structure of miz-1 zinc fingers 3 and 4
Structure deposition date
2015-04-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
0
Peptide accession
Q13105
Residue number A
364
Residue number B
367
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 364 of Zinc finger and BTB domain-containing protein 17
Cysteine 367 of Zinc finger and BTB domain-containing protein 17
7mc3 A 62 A 65
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 616 and 619 (62 and 65 respectively in this structure).
Details
Redox score ?
85
PDB code
7mc3
Structure name
solution structure of miz-1 zinc finger 12
Structure deposition date
2021-04-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
0
Peptide accession
Q13105
Residue number A
616
Residue number B
619
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 616 of Zinc finger and BTB domain-containing protein 17
Cysteine 619 of Zinc finger and BTB domain-containing protein 17
2n25 A 34 A 37
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 336 and 339 (34 and 37 respectively in this structure).
Details
Redox score ?
85
PDB code
2n25
Structure name
solution structure of miz-1 zinc finger 2
Structure deposition date
2015-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
336
Residue number B
339
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 336 of Zinc finger and BTB domain-containing protein 17
Cysteine 339 of Zinc finger and BTB domain-containing protein 17
7mc2 A 34 A 37
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 588 and 591 (34 and 37 respectively in this structure).
Details
Redox score ?
84
PDB code
7mc2
Structure name
solution structure of miz-1 zinc finger 11 h586y
Structure deposition date
2021-04-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
588
Residue number B
591
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 588 of Zinc finger and BTB domain-containing protein 17
Cysteine 591 of Zinc finger and BTB domain-containing protein 17
2lvt A 34 A 37
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 532 and 535 (34 and 37 respectively in this structure).
Details
Redox score ?
84
PDB code
2lvt
Structure name
solution structure of miz-1 zinc finger 9
Structure deposition date
2012-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
532
Residue number B
535
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 532 of Zinc finger and BTB domain-containing protein 17
Cysteine 535 of Zinc finger and BTB domain-containing protein 17
5ion A 6 A 9
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 719 and 722 (6 and 9 respectively in this structure).
Details
Redox score ?
82
PDB code
5ion
Structure name
solution structure of miz-1 zinc finger 13
Structure deposition date
2016-03-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
0
Peptide accession
Q13105
Residue number A
719
Residue number B
722
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 719 of Zinc finger and BTB domain-containing protein 17
Cysteine 722 of Zinc finger and BTB domain-containing protein 17
2n26 A 90 A 93
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 392 and 395 (90 and 93 respectively in this structure).
Details
Redox score ?
81
PDB code
2n26
Structure name
solution structure of miz-1 zinc fingers 3 and 4
Structure deposition date
2015-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
Q13105
Residue number A
392
Residue number B
395
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 392 of Zinc finger and BTB domain-containing protein 17
Cysteine 395 of Zinc finger and BTB domain-containing protein 17
2n25 A 34 A 47
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 336 and 349 (34 and 47 respectively in this structure).
Details
Redox score ?
63
PDB code
2n25
Structure name
solution structure of miz-1 zinc finger 2
Structure deposition date
2015-04-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
0
Peptide accession
Q13105
Residue number A
336
Residue number B
349
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 336 of Zinc finger and BTB domain-containing protein 17
Cysteine 349 of Zinc finger and BTB domain-containing protein 17
2lvt A 32 A 34
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 530 and 532 (32 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
2lvt
Structure name
solution structure of miz-1 zinc finger 9
Structure deposition date
2012-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
530
Residue number B
532
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 530 of Zinc finger and BTB domain-containing protein 17
Cysteine 532 of Zinc finger and BTB domain-containing protein 17
2n25 A 37 A 47
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 339 and 349 (37 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2n25
Structure name
solution structure of miz-1 zinc finger 2
Structure deposition date
2015-04-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
Q13105
Residue number A
339
Residue number B
349
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 339 of Zinc finger and BTB domain-containing protein 17
Cysteine 349 of Zinc finger and BTB domain-containing protein 17
2n26 A 62 A 93
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 364 and 395 (62 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
2n26
Structure name
solution structure of miz-1 zinc fingers 3 and 4
Structure deposition date
2015-04-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q13105
Residue number A
364
Residue number B
395
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 364 of Zinc finger and BTB domain-containing protein 17
Cysteine 395 of Zinc finger and BTB domain-containing protein 17
7azx A 24 A 26
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 17 between cysteines 24 and 26. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7azx
Structure name
crystal structure of the miz1-btb-domain in complex with a huwe1- derived peptide
Structure deposition date
2020-11-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
74
Peptide accession
Q13105
Residue number A
24
Residue number B
26
Peptide name
Zinc finger and BTB domain-containing protein 17
Ligandability
Cysteine 24 of Zinc finger and BTB domain-containing protein 17
Cysteine 26 of Zinc finger and BTB domain-containing protein 17
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