TNF receptor-associated factor 3
Intermolecular
Cysteine 533 and cysteine 140 of Mitochondrial antiviral-signaling protein
Cysteine 534 and cysteine 177 of TRAF family member-associated NF-kappa-B activator
Intramolecular
Cysteine 68 and cysteine 88
Cysteine 53 and cysteine 76
Cysteine 53 and cysteine 56
Cysteine 68 and cysteine 91
Cysteine 53 and cysteine 73
Cysteine 73 and cysteine 76
Cysteine 56 and cysteine 73
Cysteine 88 and cysteine 91
More...Cysteine 56 and cysteine 76
Cysteine 53 and cysteine 88
4ghu A 533 B 140
A redox-regulated disulphide may form between cysteine 533 of TNF receptor-associated factor 3 and cysteine 140 of Mitochondrial antiviral-signaling protein.
Details
Redox score ?
84
PDB code
4ghu
Structure name
crystal structure of traf3/cardif
Structure deposition date
2012-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
TNF receptor-associated factor 3
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
Q60803
Peptide B accession
Q8VCF0
Peptide A residue number
533
Peptide B residue number
140
Ligandability
Cysteine 533 of TNF receptor-associated factor 3
Cysteine 140 of Mitochondrial antiviral-signaling protein
1kzz A 470 B 1
A redox-regulated disulphide may form between cysteine 534 of TNF receptor-associated factor 3 and cysteine 177 of TRAF family member-associated NF-kappa-B activator (470 and 1 respectively in this structure).
Details
Redox score ?
67
PDB code
1kzz
Structure name
downstream regulator tank binds to the cd40 recognition site on traf3
Structure deposition date
2002-02-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide A name
TNF receptor-associated factor 3
Peptide B name
TRAF family member-associated NF-kappa-B activator
Peptide A accession
Q13114
Peptide B accession
Q92844
Peptide A residue number
534
Peptide B residue number
177
Ligandability
Cysteine 534 of TNF receptor-associated factor 3
Cysteine 177 of TRAF family member-associated NF-kappa-B activator
2ecy A 33 A 53
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 68 and 88 (33 and 53 respectively in this structure).
Details
Redox score ?
88
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
10
Peptide accession
Q13114
Residue number A
68
Residue number B
88
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 68 of TNF receptor-associated factor 3
Cysteine 88 of TNF receptor-associated factor 3
2ecy A 18 A 41
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 53 and 76 (18 and 41 respectively in this structure).
Details
Redox score ?
85
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
7
Peptide accession
Q13114
Residue number A
53
Residue number B
76
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 53 of TNF receptor-associated factor 3
Cysteine 76 of TNF receptor-associated factor 3
2ecy A 18 A 21
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 53 and 56 (18 and 21 respectively in this structure).
Details
Redox score ?
84
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
7
Peptide accession
Q13114
Residue number A
53
Residue number B
56
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 53 of TNF receptor-associated factor 3
Cysteine 56 of TNF receptor-associated factor 3
2ecy A 33 A 56
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 68 and 91 (33 and 56 respectively in this structure).
Details
Redox score ?
84
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
2
Peptide accession
Q13114
Residue number A
68
Residue number B
91
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 68 of TNF receptor-associated factor 3
Cysteine 91 of TNF receptor-associated factor 3
2ecy A 18 A 38
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 53 and 73 (18 and 38 respectively in this structure).
Details
Redox score ?
82
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
8
Peptide accession
Q13114
Residue number A
53
Residue number B
73
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 53 of TNF receptor-associated factor 3
Cysteine 73 of TNF receptor-associated factor 3
2ecy A 38 A 41
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 73 and 76 (38 and 41 respectively in this structure).
Details
Redox score ?
81
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
0
Peptide accession
Q13114
Residue number A
73
Residue number B
76
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 73 of TNF receptor-associated factor 3
Cysteine 76 of TNF receptor-associated factor 3
2ecy A 21 A 38
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 56 and 73 (21 and 38 respectively in this structure).
Details
Redox score ?
80
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
0
Peptide accession
Q13114
Residue number A
56
Residue number B
73
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 56 of TNF receptor-associated factor 3
Cysteine 73 of TNF receptor-associated factor 3
2ecy A 53 A 56
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 88 and 91 (53 and 56 respectively in this structure).
Details
Redox score ?
79
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
8
Peptide accession
Q13114
Residue number A
88
Residue number B
91
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 88 of TNF receptor-associated factor 3
Cysteine 91 of TNF receptor-associated factor 3
2ecy A 21 A 41
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 56 and 76 (21 and 41 respectively in this structure).
Details
Redox score ?
76
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
0
Peptide accession
Q13114
Residue number A
56
Residue number B
76
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 56 of TNF receptor-associated factor 3
Cysteine 76 of TNF receptor-associated factor 3
2ecy A 18 A 53
A redox-regulated disulphide may form within TNF receptor-associated factor 3 between cysteines 53 and 88 (18 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2ecy
Structure name
solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3
Structure deposition date
2007-02-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
15
Peptide accession
Q13114
Residue number A
53
Residue number B
88
Peptide name
TNF receptor-associated factor 3
Ligandability
Cysteine 53 of TNF receptor-associated factor 3
Cysteine 88 of TNF receptor-associated factor 3
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