ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Krueppel-like factor 10

Intramolecular
Cysteine 371 and cysteine 376
Cysteine 401 and cysteine 406
A redox-regulated disulphide may form within Krueppel-like factor 10 between cysteines 371 and 376 (20 and 25 respectively in this structure).

Details

Redox score ?
83
PDB code
2epa
Structure name
solution structure of the first and second zf-c2h2 domains from human krueppel-like factor 10
Structure deposition date
2007-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
Q13118
Residue number A
371
Residue number B
376
Peptide name
Krueppel-like factor 10

Ligandability

Cysteine 371 of Krueppel-like factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of Krueppel-like factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Krueppel-like factor 10 between cysteines 401 and 406 (50 and 55 respectively in this structure).

Details

Redox score ?
83
PDB code
2epa
Structure name
solution structure of the first and second zf-c2h2 domains from human krueppel-like factor 10
Structure deposition date
2007-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
Q13118
Residue number A
401
Residue number B
406
Peptide name
Krueppel-like factor 10

Ligandability

Cysteine 401 of Krueppel-like factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 406 of Krueppel-like factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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