Serine/threonine-protein kinase PAK 1

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase PAK 1 at cysteines 360 and 360. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4zlo

Structure name

serine/threonine-protein kinase pak1 complexed with a dibenzodiazepine: identification of an allosteric site on pak1

Structure deposition date

2015-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Serine/threonine-protein kinase PAK 1

Peptide B name

Serine/threonine-protein kinase PAK 1

Peptide A accession

Q13153

Peptide B accession

Q13153

Peptide A residue number

360

Peptide B residue number

360

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase PAK 1 between cysteines 370 and 501. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5kbq

Structure name

pak1 in complex with bis-anilino pyrimidine inhibitor

Structure deposition date

2016-06-03

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q13153

Residue number A

370

Residue number B

501

Peptide name

Serine/threonine-protein kinase PAK 1

Ligandability

Cysteine 370 of Serine/threonine-protein kinase PAK 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 501 of Serine/threonine-protein kinase PAK 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase PAK 1 between cysteines 370 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?