ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Intermolecular
Cysteine 105 of Bifunctional glutamate/proline--tRNA ligase and cysteine 205
Intramolecular
Cysteine 143 and cysteine 168
A redox-regulated disulphide may form between cysteine 105 of Bifunctional glutamate/proline--tRNA ligase and cysteine 205 of Aminoacyl tRNA synthase complex-interacting multifunctional protein 2.

Details

Redox score ?
78
PDB code
5a34
Structure name
the crystal structure of the gst-like domains complex of eprs-aimp2
Structure deposition date
2015-05-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
88
Peptide A name
Bifunctional glutamate/proline--tRNA ligase
Peptide B name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Peptide A accession
P07814
Peptide B accession
Q13155
Peptide A residue number
105
Peptide B residue number
205

Ligandability

Cysteine 105 of Bifunctional glutamate/proline--tRNA ligase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 between cysteines 143 and 168. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5a5h
Structure name
the crystal structure of the gst-like domains complex of eprs c92sc105sc123s mutant-aimp2
Structure deposition date
2015-06-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
49
Peptide accession
Q13155
Residue number A
143
Residue number B
168
Peptide name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Ligandability

Cysteine 143 of Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: