ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DnaJ homolog subfamily C member 3

Intramolecular
Cysteine 248 and cysteine 258
Cysteine 313 and cysteine 329
Cysteine 313 and cysteine 315
A redox-regulated disulphide may form within DnaJ homolog subfamily C member 3 between cysteines 248 and 258.

Details

Redox score ?
85
PDB code
3ieg
Structure name
crystal structure of p58(ipk) tpr domain at 2
Structure deposition date
2009-07-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91YW3
Residue number A
248
Residue number B
258
Peptide name
DnaJ homolog subfamily C member 3

Ligandability

Cysteine 248 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 3 between cysteines 313 and 329.

Details

Redox score ?
82
PDB code
3ieg
Structure name
crystal structure of p58(ipk) tpr domain at 2
Structure deposition date
2009-07-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91YW3
Residue number A
313
Residue number B
329
Peptide name
DnaJ homolog subfamily C member 3

Ligandability

Cysteine 313 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 3 between cysteines 313 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3ieg
Structure name
crystal structure of p58(ipk) tpr domain at 2
Structure deposition date
2009-07-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
nan
Peptide accession
Q91YW3
Residue number A
313
Residue number B
315
Peptide name
DnaJ homolog subfamily C member 3

Ligandability

Cysteine 313 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of DnaJ homolog subfamily C member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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