Glutamate receptor ionotropic, NMDA 2B
Intermolecular
Cysteine 946 and cysteine 946
Intramolecular
Cysteine 436 and cysteine 457
Cysteine 746 and cysteine 801
Cysteine 429 and cysteine 456
Cysteine 86 and cysteine 321
Cysteine 456 and cysteine 457
Cysteine 429 and cysteine 457
Cysteine 429 and cysteine 436
Cysteine 436 and cysteine 456
Cysteine 436 and cysteine 461
Cysteine 457 and cysteine 461
6cna B 214 D 214
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, NMDA 2B at cysteines 946 and 946 (214 and 214 respectively in this structure).
Details
Redox score ?
68
PDB code
6cna
Structure name
glun1-glun2b nmda receptors with exon 5
Structure deposition date
2018-03-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
21
Peptide A name
Glutamate receptor ionotropic, NMDA 2B
Peptide B name
Glutamate receptor ionotropic, NMDA 2B
Peptide A accession
Q00960
Peptide B accession
Q00960
Peptide A residue number
946
Peptide B residue number
946
Ligandability
7eu8 B 436 B 457
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 436 and 457.
Details
Redox score ?
83
PDB code
7eu8
Structure name
structure of the human glun1-glun2b nmda receptor in complex with s- ketamine,glycine and glutamate
Structure deposition date
2021-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13224
Residue number A
436
Residue number B
457
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 436 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 457 of Glutamate receptor ionotropic, NMDA 2B
7saa B 746 B 801
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 746 and 801.
Details
Redox score ?
82
PDB code
7saa
Structure name
glycine and glutamate bound glun1a-glun2b nmda receptors in non-active 1 conformation at 2
Structure deposition date
2021-09-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
24
Peptide accession
Q00960
Residue number A
746
Residue number B
801
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 746 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 801 of Glutamate receptor ionotropic, NMDA 2B
4pe5 B 429 B 456
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 429 and 456.
Details
Redox score ?
81
PDB code
4pe5
Structure name
crystal structure of glun1a/glun2b nmda receptor ion channel
Structure deposition date
2014-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00960
Residue number A
429
Residue number B
456
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 429 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 456 of Glutamate receptor ionotropic, NMDA 2B
7eu8 D 86 D 321
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 86 and 321.
Details
Redox score ?
73
PDB code
7eu8
Structure name
structure of the human glun1-glun2b nmda receptor in complex with s- ketamine,glycine and glutamate
Structure deposition date
2021-05-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
4
Peptide accession
Q13224
Residue number A
86
Residue number B
321
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 86 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 321 of Glutamate receptor ionotropic, NMDA 2B
7eu8 D 456 D 457
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 456 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7eu8
Structure name
structure of the human glun1-glun2b nmda receptor in complex with s- ketamine,glycine and glutamate
Structure deposition date
2021-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13224
Residue number A
456
Residue number B
457
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 456 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 457 of Glutamate receptor ionotropic, NMDA 2B
7eu8 D 429 D 457
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 429 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7eu8
Structure name
structure of the human glun1-glun2b nmda receptor in complex with s- ketamine,glycine and glutamate
Structure deposition date
2021-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13224
Residue number A
429
Residue number B
457
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 429 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 457 of Glutamate receptor ionotropic, NMDA 2B
4pe5 B 429 B 436
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 429 and 436. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
4pe5
Structure name
crystal structure of glun1a/glun2b nmda receptor ion channel
Structure deposition date
2014-04-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00960
Residue number A
429
Residue number B
436
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 429 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 436 of Glutamate receptor ionotropic, NMDA 2B
4pe5 D 436 D 456
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 436 and 456. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4pe5
Structure name
crystal structure of glun1a/glun2b nmda receptor ion channel
Structure deposition date
2014-04-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00960
Residue number A
436
Residue number B
456
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 436 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 456 of Glutamate receptor ionotropic, NMDA 2B
7sad B 436 B 461
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 436 and 461. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7sad
Structure name
memantine-bound glun1a-glun2b nmda receptors
Structure deposition date
2021-09-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide accession
Q00960
Residue number A
436
Residue number B
461
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 436 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 461 of Glutamate receptor ionotropic, NMDA 2B
7tet B 457 B 461
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 2B between cysteines 457 and 461. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7tet
Structure name
cryo-em structure of glun1b-2b nmdar in complex with fab5 in non- active2-like conformation
Structure deposition date
2022-01-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide accession
Q00960
Residue number A
457
Residue number B
461
Peptide name
Glutamate receptor ionotropic, NMDA 2B
Ligandability
Cysteine 457 of Glutamate receptor ionotropic, NMDA 2B
Cysteine 461 of Glutamate receptor ionotropic, NMDA 2B
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