Mitogen-activated protein kinase kinase kinase 1
Intramolecular
Cysteine 635 and cysteine 636
Cysteine 691 and cysteine 759
Cysteine 635 and cysteine 643
Cysteine 710 and cysteine 740
Cysteine 636 and cysteine 643
6whb A 635 A 636
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 1 between cysteines 635 and 636. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6whb
Structure name
mekk1 tog domain (548-867)
Structure deposition date
2020-04-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
98
Peptide accession
Q13233
Residue number A
635
Residue number B
636
Peptide name
Mitogen-activated protein kinase kinase kinase 1
Ligandability
Cysteine 635 of Mitogen-activated protein kinase kinase kinase 1
Cysteine 636 of Mitogen-activated protein kinase kinase kinase 1
6whb A 691 A 759
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 1 between cysteines 691 and 759. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6whb
Structure name
mekk1 tog domain (548-867)
Structure deposition date
2020-04-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
84
Peptide accession
Q13233
Residue number A
691
Residue number B
759
Peptide name
Mitogen-activated protein kinase kinase kinase 1
Ligandability
Cysteine 691 of Mitogen-activated protein kinase kinase kinase 1
Cysteine 759 of Mitogen-activated protein kinase kinase kinase 1
6whb A 635 A 643
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 1 between cysteines 635 and 643. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6whb
Structure name
mekk1 tog domain (548-867)
Structure deposition date
2020-04-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q13233
Residue number A
635
Residue number B
643
Peptide name
Mitogen-activated protein kinase kinase kinase 1
Ligandability
Cysteine 635 of Mitogen-activated protein kinase kinase kinase 1
Cysteine 643 of Mitogen-activated protein kinase kinase kinase 1
6whb A 710 A 740
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 1 between cysteines 710 and 740. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6whb
Structure name
mekk1 tog domain (548-867)
Structure deposition date
2020-04-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
84
Peptide accession
Q13233
Residue number A
710
Residue number B
740
Peptide name
Mitogen-activated protein kinase kinase kinase 1
Ligandability
Cysteine 710 of Mitogen-activated protein kinase kinase kinase 1
Cysteine 740 of Mitogen-activated protein kinase kinase kinase 1
6whb A 636 A 643
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 1 between cysteines 636 and 643. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6whb
Structure name
mekk1 tog domain (548-867)
Structure deposition date
2020-04-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
98
Peptide accession
Q13233
Residue number A
636
Residue number B
643
Peptide name
Mitogen-activated protein kinase kinase kinase 1
Ligandability
Cysteine 636 of Mitogen-activated protein kinase kinase kinase 1
Cysteine 643 of Mitogen-activated protein kinase kinase kinase 1
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