ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Metabotropic glutamate receptor 1

Intermolecular
Cysteine 601 and cysteine 601
Intramolecular
Cysteine 550 and cysteine 562
Cysteine 565 and cysteine 578
Cysteine 432 and cysteine 439
Cysteine 528 and cysteine 547
Cysteine 378 and cysteine 394
Cysteine 524 and cysteine 544
Cysteine 67 and cysteine 109
Cysteine 543 and cysteine 544
Cysteine 524 and cysteine 543
More...
Cysteine 657 and cysteine 746
Cysteine 289 and cysteine 291
Cysteine 254 and cysteine 543
Cysteine 254 and cysteine 544
Cysteine 254 and cysteine 524
Cysteine 562 and cysteine 565
Cysteine 528 and cysteine 550
Cysteine 544 and cysteine 547
Cysteine 524 and cysteine 547
Cysteine 562 and cysteine 578
Cysteine 767 and cysteine 795
Cysteine 524 and cysteine 528
Cysteine 528 and cysteine 544
Cysteine 671 and cysteine 816
Cysteine 644 and cysteine 816
Cysteine 671 and cysteine 767
Cysteine 644 and cysteine 671
A redox-regulated disulphide may form between two units of Metabotropic glutamate receptor 1 at cysteines 601 and 601. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4or2
Structure name
human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Structure deposition date
2014-02-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
13
% buried
92
Peptide A name
Metabotropic glutamate receptor 1
Peptide B name
Metabotropic glutamate receptor 1
Peptide A accession
Q13255
Peptide B accession
Q13255
Peptide A residue number
601
Peptide B residue number
601

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 550 and 562.

Details

Redox score ?
89
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
550
Residue number B
562
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 550 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 565 and 578.

Details

Redox score ?
89
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
565
Residue number B
578
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 565 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 432 and 439.

Details

Redox score ?
88
PDB code
1ewt
Structure name
crystal structure of metabotropic glutamate receptor subtype 1 ligand free form i
Structure deposition date
2000-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23385
Residue number A
432
Residue number B
439
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 432 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 439 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 528 and 547.

Details

Redox score ?
87
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
528
Residue number B
547
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 528 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 547 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 378 and 394.

Details

Redox score ?
86
PDB code
1iss
Structure name
crystal structure of metabotropic glutamate receptor subtype 1 complexed with an antagonist
Structure deposition date
2001-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23385
Residue number A
378
Residue number B
394
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 378 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 524 and 544.

Details

Redox score ?
84
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
524
Residue number B
544
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 524 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 67 and 109.

Details

Redox score ?
83
PDB code
1ewv
Structure name
crystal structure of metabotropic glutamate receptor subtype 1 ligand free form ii
Structure deposition date
2000-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23385
Residue number A
67
Residue number B
109
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 67 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 543 and 544.

Details

Redox score ?
75
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
543
Residue number B
544
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 543 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 524 and 543.

Details

Redox score ?
69
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
nan
Peptide accession
Q13255
Residue number A
524
Residue number B
543
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 524 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 543 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 657 and 746.

Details

Redox score ?
67
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
34
Peptide accession
Q13255
Residue number A
657
Residue number B
746
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 657 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 746 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 289 and 291.

Details

Redox score ?
63
PDB code
1ewk
Structure name
crystal structure of metabotropic glutamate receptor subtype 1 complexed with glutamate
Structure deposition date
2000-04-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
50
Peptide accession
P23385
Residue number A
289
Residue number B
291
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 289 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 254 and 543. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
34
Peptide accession
Q13255
Residue number A
254
Residue number B
543
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 254 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 543 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 254 and 544. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
254
Residue number B
544
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 254 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 254 and 524. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
nan
Peptide accession
Q13255
Residue number A
254
Residue number B
524
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 254 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 524 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 562 and 565. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
562
Residue number B
565
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 562 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 528 and 550. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
528
Residue number B
550
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 528 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 550 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 544 and 547. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
544
Residue number B
547
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 544 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 547 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 524 and 547. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
524
Residue number B
547
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 524 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 547 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 562 and 578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
562
Residue number B
578
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 562 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 767 and 795. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4or2
Structure name
human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Structure deposition date
2014-02-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
74
Peptide accession
Q13255
Residue number A
767
Residue number B
795
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 767 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 795 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 524 and 528. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
524
Residue number B
528
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 524 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 528 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 528 and 544. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7dgd
Structure name
apo state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13255
Residue number A
528
Residue number B
544
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 528 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 671 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7dge
Structure name
intermediate state of class c gpcr
Structure deposition date
2020-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
88
Peptide accession
Q13255
Residue number A
671
Residue number B
816
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 671 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 816 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 644 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4or2
Structure name
human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Structure deposition date
2014-02-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q13255
Residue number A
644
Residue number B
816
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 644 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 816 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 671 and 767. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4or2
Structure name
human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Structure deposition date
2014-02-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q13255
Residue number A
671
Residue number B
767
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 671 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 767 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 1 between cysteines 644 and 671. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4or2
Structure name
human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Structure deposition date
2014-02-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q13255
Residue number A
644
Residue number B
671
Peptide name
Metabotropic glutamate receptor 1

Ligandability

Cysteine 644 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 671 of Metabotropic glutamate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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