ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitotic spindle assembly checkpoint protein MAD2A

Intramolecular
Cysteine 79 and cysteine 106
A redox-regulated disulphide may form within Mitotic spindle assembly checkpoint protein MAD2A between cysteines 79 and 106.

Details

Redox score ?
70
PDB code
1go4
Structure name
crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20
Structure deposition date
2001-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
60
Peptide accession
Q13257
Residue number A
79
Residue number B
106
Peptide name
Mitotic spindle assembly checkpoint protein MAD2A

Ligandability

Cysteine 79 of Mitotic spindle assembly checkpoint protein MAD2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Mitotic spindle assembly checkpoint protein MAD2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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