ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-15 receptor subunit alpha

Intramolecular
Cysteine 33 and cysteine 75
Cysteine 59 and cysteine 93
A redox-regulated disulphide may form within Interleukin-15 receptor subunit alpha between cysteines 33 and 75 (3 and 45 respectively in this structure).

Details

Redox score ?
87
PDB code
4gs7
Structure name
structure of the interleukin-15 quaternary complex
Structure deposition date
2012-08-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13261
Residue number A
33
Residue number B
75
Peptide name
Interleukin-15 receptor subunit alpha

Ligandability

Cysteine 33 of Interleukin-15 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Interleukin-15 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-15 receptor subunit alpha between cysteines 59 and 93 (29 and 63 respectively in this structure).

Details

Redox score ?
86
PDB code
4gs7
Structure name
structure of the interleukin-15 quaternary complex
Structure deposition date
2012-08-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13261
Residue number A
59
Residue number B
93
Peptide name
Interleukin-15 receptor subunit alpha

Ligandability

Cysteine 59 of Interleukin-15 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Interleukin-15 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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