ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Inactive tyrosine-protein kinase 7

Intramolecular
Cysteine 911 and cysteine 1032
Cysteine 911 and cysteine 1043
Cysteine 911 and cysteine 936
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase 7 between cysteines 911 and 1032. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6vg3
Structure name
structure of unliganded, inactive ptk7 kinase domain
Structure deposition date
2020-01-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
73
Peptide accession
Q13308
Residue number A
911
Residue number B
1032
Peptide name
Inactive tyrosine-protein kinase 7

Ligandability

Cysteine 911 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1032 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive tyrosine-protein kinase 7 between cysteines 911 and 1043. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
6vg3
Structure name
structure of unliganded, inactive ptk7 kinase domain
Structure deposition date
2020-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q13308
Residue number A
911
Residue number B
1043
Peptide name
Inactive tyrosine-protein kinase 7

Ligandability

Cysteine 911 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1043 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive tyrosine-protein kinase 7 between cysteines 911 and 936. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
6vg3
Structure name
structure of unliganded, inactive ptk7 kinase domain
Structure deposition date
2020-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
Q13308
Residue number A
911
Residue number B
936
Peptide name
Inactive tyrosine-protein kinase 7

Ligandability

Cysteine 911 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 936 of Inactive tyrosine-protein kinase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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