Corticotropin-releasing factor receptor 2
Intramolecular
Cysteine 14 and cysteine 50
Cysteine 146 and cysteine 50
Cysteine 64 and cysteine 98
Cysteine 40 and cysteine 50
Cysteine 40 and cysteine 83
Cysteine 184 and cysteine 254
Cysteine 184 and cysteine 186
1u34 A 45 A 70
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 14 and 50 (45 and 70 respectively in this structure).
Details
Redox score ?
89
PDB code
1u34
Structure name
3d nmr structure of the first extracellular domain of crfr-2beta, a type b1 g-protein coupled receptor
Structure deposition date
2004-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60748
Residue number A
14
Residue number B
50
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 14 of Corticotropin-releasing factor receptor 2
Cysteine 50 of Corticotropin-releasing factor receptor 2
2jnc A 45 A 70
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 146 and 50 (45 and 70 respectively in this structure).
Details
Redox score ?
87
PDB code
2jnc
Structure name
refined 3d nmr structure of ecd1 of mcrf-r2beta at ph 5
Structure deposition date
2007-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60748
Residue number A
146
Residue number B
50
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 146 of Corticotropin-releasing factor receptor 2
Cysteine 50 of Corticotropin-releasing factor receptor 2
1u34 A 84 A 118
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 64 and 98 (84 and 118 respectively in this structure).
Details
Redox score ?
87
PDB code
1u34
Structure name
3d nmr structure of the first extracellular domain of crfr-2beta, a type b1 g-protein coupled receptor
Structure deposition date
2004-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60748
Residue number A
64
Residue number B
98
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 64 of Corticotropin-releasing factor receptor 2
Cysteine 98 of Corticotropin-releasing factor receptor 2
2jnd A 45 A 70
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 40 and 50 (45 and 70 respectively in this structure).
Details
Redox score ?
86
PDB code
2jnd
Structure name
3d nmr structure of ecd1 of mcrf-r2b in complex with astressin
Structure deposition date
2007-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60748
Residue number A
40
Residue number B
50
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 40 of Corticotropin-releasing factor receptor 2
Cysteine 50 of Corticotropin-releasing factor receptor 2
Uncertain whether structure cysteine 45 has been assigned to correct residue.
2jnc A 60 A 103
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 40 and 83 (60 and 103 respectively in this structure).
Details
Redox score ?
86
PDB code
2jnc
Structure name
refined 3d nmr structure of ecd1 of mcrf-r2beta at ph 5
Structure deposition date
2007-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q60748
Residue number A
40
Residue number B
83
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 40 of Corticotropin-releasing factor receptor 2
Cysteine 83 of Corticotropin-releasing factor receptor 2
7ts0 P 184 P 254
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 184 and 254.
Details
Redox score ?
85
PDB code
7ts0
Structure name
cryo-em structure of corticotropin releasing factor receptor 2 bound to urocortin 1 and coupled with heterotrimeric go protein
Structure deposition date
2022-01-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13324
Residue number A
184
Residue number B
254
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 184 of Corticotropin-releasing factor receptor 2
Cysteine 254 of Corticotropin-releasing factor receptor 2
6pb1 P 184 P 186
A redox-regulated disulphide may form within Corticotropin-releasing factor receptor 2 between cysteines 184 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6pb1
Structure name
cryo-em structure of urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs protein and nb35
Structure deposition date
2019-06-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
nan
Peptide accession
Q13324
Residue number A
184
Residue number B
186
Peptide name
Corticotropin-releasing factor receptor 2
Ligandability
Cysteine 184 of Corticotropin-releasing factor receptor 2
Cysteine 186 of Corticotropin-releasing factor receptor 2
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