Interferon-induced protein with tetratricopeptide repeats 5

Intramolecular

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 5 between cysteines 124 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4hor

Structure name

crystal structure of full-length human ifit5 with 5`-triphosphate oligocytidine

Structure deposition date

2012-10-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q13325

Residue number A

124

Residue number B

137

Peptide name

Interferon-induced protein with tetratricopeptide repeats 5

Ligandability

Cysteine 124 of Interferon-induced protein with tetratricopeptide repeats 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Interferon-induced protein with tetratricopeptide repeats 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 5 between cysteines 137 and 142. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?