a tool for identifying drug-targetable redox-active disulphides

Metastasis-associated protein MTA1

Intramolecular

Cysteine 486 and cysteine 512

A redox-regulated disulphide may form within Metastasis-associated protein MTA1 between cysteines 486 and 512.

Details

Redox score ?

71

PDB code

Structure name

structure of the human rbbp4:mta1(464-546) complex showing loop exchange

Structure deposition date

2018-03-20

Thiol separation (Å)

5

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

14

Peptide accession

Residue number A

486

Residue number B

512

Peptide name

Metastasis-associated protein MTA1

Ligandability

Cysteine 486 of Metastasis-associated protein MTA1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Metastasis-associated protein MTA1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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