ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Urea transporter 1

Intramolecular
Cysteine 87 and cysteine 231
Cysteine 294 and cysteine 315
A redox-regulated disulphide may form within Urea transporter 1 between cysteines 87 and 231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4ezd
Structure name
crystal structure of the ut-b urea transporter from bos taurus bound to selenourea
Structure deposition date
2012-05-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
79
Peptide accession
Q5QF96
Residue number A
87
Residue number B
231
Peptide name
Urea transporter 1

Ligandability

Cysteine 87 of Urea transporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Urea transporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urea transporter 1 between cysteines 294 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6qd5
Structure name
x-ray structure of the human urea channel slc14a1/ut1
Structure deposition date
2018-12-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
98
Peptide accession
Q13336
Residue number A
294
Residue number B
315
Peptide name
Urea transporter 1

Ligandability

Cysteine 294 of Urea transporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Urea transporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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