ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-terminal-binding protein 1

Intramolecular
Cysteine 118 and cysteine 350
Cysteine 38 and cysteine 54
A redox-regulated disulphide may form within C-terminal-binding protein 1 between cysteines 118 and 350.

Details

Redox score ?
75
PDB code
6v89
Structure name
human ctbp1 (28-375) in complex with amp
Structure deposition date
2019-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
6
% buried
62
Peptide accession
Q13363
Residue number A
118
Residue number B
350
Peptide name
C-terminal-binding protein 1

Ligandability

Cysteine 118 of C-terminal-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 350 of C-terminal-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-terminal-binding protein 1 between cysteines 38 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4lce
Structure name
ctbp1 in complex with substrate mtob
Structure deposition date
2013-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
41
Peptide accession
Q13363
Residue number A
38
Residue number B
54
Peptide name
C-terminal-binding protein 1

Ligandability

Cysteine 38 of C-terminal-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of C-terminal-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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