ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Putative nucleotidyltransferase MAB21L1

Intermolecular
Cysteine 246 and cysteine 313
Intramolecular
Cysteine 97 and cysteine 215
Cysteine 310 and cysteine 316
Cysteine 246 and cysteine 250
Cysteine 310 and cysteine 313
Cysteine 246 and cysteine 295
Cysteine 313 and cysteine 316
Cysteine 246 and cysteine 282
Cysteine 250 and cysteine 282
Cysteine 20 and cysteine 250
Cysteine 250 and cysteine 295
A redox-regulated disulphide may form between two units of Putative nucleotidyltransferase MAB21L1 at cysteines 246 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
86
Peptide A name
Putative nucleotidyltransferase MAB21L1
Peptide B name
Putative nucleotidyltransferase MAB21L1
Peptide A accession
Q13394
Peptide B accession
Q13394
Peptide A residue number
246
Peptide B residue number
313

Ligandability

Cysteine 246 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 97 and 215.

Details

Redox score ?
78
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
50
Peptide accession
Q13394
Residue number A
97
Residue number B
215
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 97 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 310 and 316.

Details

Redox score ?
76
PDB code
5eog
Structure name
structure of full-length human mab21l1
Structure deposition date
2015-11-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
94
Peptide accession
Q13394
Residue number A
310
Residue number B
316
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 310 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 246 and 250.

Details

Redox score ?
64
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
95
Peptide accession
Q13394
Residue number A
246
Residue number B
250
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 246 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 310 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5eog
Structure name
structure of full-length human mab21l1
Structure deposition date
2015-11-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
92
Peptide accession
Q13394
Residue number A
310
Residue number B
313
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 310 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 246 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
60
Peptide accession
Q13394
Residue number A
246
Residue number B
295
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 246 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 313 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5eog
Structure name
structure of full-length human mab21l1
Structure deposition date
2015-11-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
87
Peptide accession
Q13394
Residue number A
313
Residue number B
316
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 313 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 246 and 282. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5eog
Structure name
structure of full-length human mab21l1
Structure deposition date
2015-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
92
Peptide accession
Q13394
Residue number A
246
Residue number B
282
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 246 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 250 and 282. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
98
Peptide accession
Q13394
Residue number A
250
Residue number B
282
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 250 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 20 and 250. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5eog
Structure name
structure of full-length human mab21l1
Structure deposition date
2015-11-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
92
Peptide accession
Q13394
Residue number A
20
Residue number B
250
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 20 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Putative nucleotidyltransferase MAB21L1 between cysteines 250 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5eom
Structure name
structure of full-length human mab21l1 with bound ctp
Structure deposition date
2015-11-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
72
Peptide accession
Q13394
Residue number A
250
Residue number B
295
Peptide name
Putative nucleotidyltransferase MAB21L1

Ligandability

Cysteine 250 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Putative nucleotidyltransferase MAB21L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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