ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Probable methyltransferase TARBP1

Intramolecular
Cysteine 1481 and cysteine 1499
Cysteine 1481 and cysteine 1484
A redox-regulated disulphide may form within Probable methyltransferase TARBP1 between cysteines 1481 and 1499 (44 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2ha8
Structure name
methyltransferase domain of human tar (hiv-1) rna binding protein 1
Structure deposition date
2006-06-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
66
Peptide accession
Q13395
Residue number A
1481
Residue number B
1499
Peptide name
Probable methyltransferase TARBP1

Ligandability

Cysteine 1481 of Probable methyltransferase TARBP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1499 of Probable methyltransferase TARBP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable methyltransferase TARBP1 between cysteines 1481 and 1484 (44 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2ha8
Structure name
methyltransferase domain of human tar (hiv-1) rna binding protein 1
Structure deposition date
2006-06-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
99
Minimum pKa ?
13
% buried
90
Peptide accession
Q13395
Residue number A
1481
Residue number B
1484
Peptide name
Probable methyltransferase TARBP1

Ligandability

Cysteine 1481 of Probable methyltransferase TARBP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1484 of Probable methyltransferase TARBP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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