ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Unconventional myosin-VIIa

Intramolecular
Cysteine 1864 and cysteine 1870
Cysteine 1198 and cysteine 1201
Cysteine 1840 and cysteine 1870
Cysteine 1198 and cysteine 1227
A redox-regulated disulphide may form within Unconventional myosin-VIIa between cysteines 1864 and 1870. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5mv9
Structure name
structure of human myosin 7a c-terminal myth4-ferm domain in complex with harmonin-a pdz3 domain
Structure deposition date
2017-01-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
68
Peptide accession
Q13402
Residue number A
1864
Residue number B
1870
Peptide name
Unconventional myosin-VIIa

Ligandability

Cysteine 1864 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1870 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIa between cysteines 1198 and 1201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3pvl
Structure name
structure of myosin viia myth4-ferm-sh3 in complex with the cen1 of sans
Structure deposition date
2010-12-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
Q5MJ57
Residue number A
1198
Residue number B
1201
Peptide name
Unconventional myosin-VIIa

Ligandability

Cysteine 1198 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1201 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIa between cysteines 1840 and 1870. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5mv9
Structure name
structure of human myosin 7a c-terminal myth4-ferm domain in complex with harmonin-a pdz3 domain
Structure deposition date
2017-01-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q13402
Residue number A
1840
Residue number B
1870
Peptide name
Unconventional myosin-VIIa

Ligandability

Cysteine 1840 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1870 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIa between cysteines 1198 and 1227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
3pvl
Structure name
structure of myosin viia myth4-ferm-sh3 in complex with the cen1 of sans
Structure deposition date
2010-12-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
92
Peptide accession
Q5MJ57
Residue number A
1198
Residue number B
1227
Peptide name
Unconventional myosin-VIIa

Ligandability

Cysteine 1198 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1227 of Unconventional myosin-VIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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