ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytoplasmic dynein 1 intermediate chain 2

Intermolecular
Cysteine 284 and cysteine 284
Intramolecular
Cysteine 284 and cysteine 386
Cysteine 284 and cysteine 95
A redox-regulated disulphide may form between two units of Cytoplasmic dynein 1 intermediate chain 2 at cysteines 284 and 284 (69 and 228 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5jpw
Structure name
molecular basis for protein recognition specificity of the dynlt1/tctex1 canonical binding groove
Structure deposition date
2016-05-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
68
Peptide A name
Cytoplasmic dynein 1 intermediate chain 2
Peptide B name
Cytoplasmic dynein 1 intermediate chain 2
Peptide A accession
Q13409
Peptide B accession
Q13409
Peptide A residue number
284
Peptide B residue number
284

Ligandability

Cysteine 284 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 1 intermediate chain 2 between cysteines 284 and 386 (69 and 106 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5jpw
Structure name
molecular basis for protein recognition specificity of the dynlt1/tctex1 canonical binding groove
Structure deposition date
2016-05-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
60
Peptide accession
Q13409
Residue number A
284
Residue number B
386
Peptide name
Cytoplasmic dynein 1 intermediate chain 2

Ligandability

Cysteine 284 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 1 intermediate chain 2 between cysteines 284 and 95 (85 and 95 respectively in this structure).

Details

Redox score ?
nan
PDB code
5jpw
Structure name
molecular basis for protein recognition specificity of the dynlt1/tctex1 canonical binding groove
Structure deposition date
2016-05-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
64
Peptide accession
Q13409
Residue number A
284
Residue number B
95
Peptide name
Cytoplasmic dynein 1 intermediate chain 2

Ligandability

Cysteine 284 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Cytoplasmic dynein 1 intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 in protein B could not be asigned to a Uniprot residue.
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