ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Butyrophilin subfamily 1 member A1

Intramolecular
Cysteine 164 and cysteine 218
Cysteine 50 and cysteine 124
A redox-regulated disulphide may form within Butyrophilin subfamily 1 member A1 between cysteines 164 and 218 (138 and 192 respectively in this structure).

Details

Redox score ?
81
PDB code
4hh8
Structure name
crystal structure of bovine butyrophilin
Structure deposition date
2012-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18892
Residue number A
164
Residue number B
218
Peptide name
Butyrophilin subfamily 1 member A1

Ligandability

Cysteine 164 of Butyrophilin subfamily 1 member A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Butyrophilin subfamily 1 member A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Butyrophilin subfamily 1 member A1 between cysteines 50 and 124 (24 and 98 respectively in this structure).

Details

Redox score ?
80
PDB code
4hh8
Structure name
crystal structure of bovine butyrophilin
Structure deposition date
2012-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18892
Residue number A
50
Residue number B
124
Peptide name
Butyrophilin subfamily 1 member A1

Ligandability

Cysteine 50 of Butyrophilin subfamily 1 member A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Butyrophilin subfamily 1 member A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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