ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Origin recognition complex subunit 1

Intermolecular
Cysteine 829 and cysteine 194 of Origin recognition complex subunit 4
Intramolecular
Cysteine 722 and cysteine 726
A redox-regulated disulphide may form between cysteine 829 of Origin recognition complex subunit 1 and cysteine 194 of Origin recognition complex subunit 4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5uj7
Structure name
structure of the active form of human origin recognition complex atpase motor module, complex subunits 1, 4, 5
Structure deposition date
2017-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide A name
Origin recognition complex subunit 1
Peptide B name
Origin recognition complex subunit 4
Peptide A accession
Q13415
Peptide B accession
O43929
Peptide A residue number
829
Peptide B residue number
194

Ligandability

Cysteine 829 of Origin recognition complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Origin recognition complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 1 between cysteines 722 and 726. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5uj7
Structure name
structure of the active form of human origin recognition complex atpase motor module, complex subunits 1, 4, 5
Structure deposition date
2017-01-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
96
Peptide accession
Q13415
Residue number A
722
Residue number B
726
Peptide name
Origin recognition complex subunit 1

Ligandability

Cysteine 722 of Origin recognition complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 726 of Origin recognition complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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