ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrin-linked protein kinase

Intramolecular
Cysteine 239 and cysteine 257
Cysteine 8 and cysteine 42
A redox-regulated disulphide may form within Integrin-linked protein kinase between cysteines 239 and 257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3kmw
Structure name
crystal structure of the ilk/alpha-parvin core complex (mgatp)
Structure deposition date
2009-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
76
Peptide accession
Q13418
Residue number A
239
Residue number B
257
Peptide name
Integrin-linked protein kinase

Ligandability

Cysteine 239 of Integrin-linked protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Integrin-linked protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin-linked protein kinase between cysteines 8 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4hi9
Structure name
1
Structure deposition date
2012-10-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
88
Peptide accession
Q13418
Residue number A
8
Residue number B
42
Peptide name
Integrin-linked protein kinase

Ligandability

Cysteine 8 of Integrin-linked protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of Integrin-linked protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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