ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Mesothelin

Intramolecular
Cysteine 302 and cysteine 326
Cysteine 450 and cysteine 476
A redox-regulated disulphide may form within Mesothelin between cysteines 302 and 326.

Details

Redox score ?
86
PDB code
8cx3
Structure name
crystal structure of full-length mesothelin
Structure deposition date
2022-05-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13421
Residue number A
302
Residue number B
326
Peptide name
Mesothelin

Ligandability

Cysteine 302 of Mesothelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Mesothelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mesothelin between cysteines 450 and 476 (442 and 468 respectively in this structure).

Details

Redox score ?
85
PDB code
7u9j
Structure name
crystal structure of mesothelin-207 fragment
Structure deposition date
2022-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13421
Residue number A
450
Residue number B
476
Peptide name
Mesothelin

Ligandability

Cysteine 450 of Mesothelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 476 of Mesothelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: