a tool for identifying drug-targetable redox-active disulphides

DNA-binding protein Ikaros

Intramolecular

Cysteine 147 and cysteine 150

A redox-regulated disulphide may form within DNA-binding protein Ikaros between cysteines 147 and 150.

Details

Redox score ?

61

PDB code

Structure name

structure of ddb1-crbn-pomalidomide complex bound to ikzf1(zf2)

Structure deposition date

2018-07-09

Thiol separation (Å)

4

Half-sphere exposure sum ?

79

Minimum pK_a ?

14

% buried

nan

Peptide accession

Residue number A

147

Residue number B

150

Peptide name

DNA-binding protein Ikaros

Ligandability

Cysteine 147 of DNA-binding protein Ikaros

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of DNA-binding protein Ikaros

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: