ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein OS-9

Intramolecular
Cysteine 181 and cysteine 216
Cysteine 110 and cysteine 123
Cysteine 196 and cysteine 228
A redox-regulated disulphide may form within Protein OS-9 between cysteines 181 and 216.

Details

Redox score ?
87
PDB code
3aih
Structure name
human os-9 mrh domain complexed with alpha3,alpha6-man5
Structure deposition date
2010-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13438
Residue number A
181
Residue number B
216
Peptide name
Protein OS-9

Ligandability

Cysteine 181 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein OS-9 between cysteines 110 and 123.

Details

Redox score ?
85
PDB code
3aih
Structure name
human os-9 mrh domain complexed with alpha3,alpha6-man5
Structure deposition date
2010-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13438
Residue number A
110
Residue number B
123
Peptide name
Protein OS-9

Ligandability

Cysteine 110 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein OS-9 between cysteines 196 and 228.

Details

Redox score ?
84
PDB code
3aih
Structure name
human os-9 mrh domain complexed with alpha3,alpha6-man5
Structure deposition date
2010-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13438
Residue number A
196
Residue number B
228
Peptide name
Protein OS-9

Ligandability

Cysteine 196 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Protein OS-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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