ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tumor suppressor candidate 3

Intermolecular
Cysteine 99 and cysteine 234 of Protein cereblon
Cysteine 99 and cysteine 216 of Interleukin-1 receptor accessory protein-like 1
Intramolecular
Cysteine 99 and cysteine 102
A redox-regulated disulphide may form between cysteine 99 of Tumor suppressor candidate 3 and cysteine 234 of Protein cereblon (58 and 6 respectively in this structure).

Details

Redox score ?
90
PDB code
4m91
Structure name
crystal structure of hn33/tusc3-peptide 1
Structure deposition date
2013-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor suppressor candidate 3
Peptide B name
Protein cereblon
Peptide A accession
Q13454
Peptide B accession
Q96SW2
Peptide A residue number
99
Peptide B residue number
234

Ligandability

Cysteine 99 of Tumor suppressor candidate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Protein cereblon

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 99 of Tumor suppressor candidate 3 and cysteine 216 of Interleukin-1 receptor accessory protein-like 1 (58 and 10 respectively in this structure).

Details

Redox score ?
88
PDB code
4m92
Structure name
crystal structure of hn33/tusc3-peptide 2
Structure deposition date
2013-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor suppressor candidate 3
Peptide B name
Interleukin-1 receptor accessory protein-like 1
Peptide A accession
Q13454
Peptide B accession
Q9NZN1
Peptide A residue number
99
Peptide B residue number
216

Ligandability

Cysteine 99 of Tumor suppressor candidate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Interleukin-1 receptor accessory protein-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor suppressor candidate 3 between cysteines 99 and 102 (58 and 61 respectively in this structure).

Details

Redox score ?
85
PDB code
4m8g
Structure name
crystal structure of se-met hn33/tusc3
Structure deposition date
2013-08-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13454
Residue number A
99
Residue number B
102
Peptide name
Tumor suppressor candidate 3

Ligandability

Cysteine 99 of Tumor suppressor candidate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Tumor suppressor candidate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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