Frizzled-5
Intramolecular
Cysteine 33 and cysteine 94
Cysteine 109 and cysteine 133
Cysteine 222 and cysteine 298
Cysteine 78 and cysteine 116
Cysteine 105 and cysteine 147
Cysteine 315 and cysteine 390
Cysteine 41 and cysteine 87
Cysteine 277 and cysteine 280
Cysteine 222 and cysteine 315
Cysteine 246 and cysteine 510
5ury B 8 B 69
A redox-regulated disulphide may form within Frizzled-5 between cysteines 33 and 94 (8 and 69 respectively in this structure).
Details
Redox score ?
84
PDB code
5ury
Structure name
crystal structure of frizzled 5 crd in complex with pam
Structure deposition date
2017-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
33
Residue number B
94
Peptide name
Frizzled-5
Ligandability
Cysteine 33 of Frizzled-5
Cysteine 94 of Frizzled-5
5urz B 84 B 108
A redox-regulated disulphide may form within Frizzled-5 between cysteines 109 and 133 (84 and 108 respectively in this structure).
Details
Redox score ?
84
PDB code
5urz
Structure name
crystal structure of frizzled 5 crd in complex with bog
Structure deposition date
2017-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
109
Residue number B
133
Peptide name
Frizzled-5
Ligandability
Cysteine 109 of Frizzled-5
Cysteine 133 of Frizzled-5
6ww2 R 222 R 298
A redox-regulated disulphide may form within Frizzled-5 between cysteines 222 and 298.
Details
Redox score ?
84
PDB code
6ww2
Structure name
structure of human frizzled5 by fiducial-assisted cryo-em
Structure deposition date
2020-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
222
Residue number B
298
Peptide name
Frizzled-5
Ligandability
Cysteine 222 of Frizzled-5
Cysteine 298 of Frizzled-5
5urz A 53 A 91
A redox-regulated disulphide may form within Frizzled-5 between cysteines 78 and 116 (53 and 91 respectively in this structure).
Details
Redox score ?
84
PDB code
5urz
Structure name
crystal structure of frizzled 5 crd in complex with bog
Structure deposition date
2017-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
78
Residue number B
116
Peptide name
Frizzled-5
Ligandability
Cysteine 78 of Frizzled-5
Cysteine 116 of Frizzled-5
5ury A 80 A 122
A redox-regulated disulphide may form within Frizzled-5 between cysteines 105 and 147 (80 and 122 respectively in this structure).
Details
Redox score ?
83
PDB code
5ury
Structure name
crystal structure of frizzled 5 crd in complex with pam
Structure deposition date
2017-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
105
Residue number B
147
Peptide name
Frizzled-5
Ligandability
Cysteine 105 of Frizzled-5
Cysteine 147 of Frizzled-5
6ww2 R 315 R 390
A redox-regulated disulphide may form within Frizzled-5 between cysteines 315 and 390.
Details
Redox score ?
82
PDB code
6ww2
Structure name
structure of human frizzled5 by fiducial-assisted cryo-em
Structure deposition date
2020-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
315
Residue number B
390
Peptide name
Frizzled-5
Ligandability
Cysteine 315 of Frizzled-5
Cysteine 390 of Frizzled-5
5urz A 16 A 62
A redox-regulated disulphide may form within Frizzled-5 between cysteines 41 and 87 (16 and 62 respectively in this structure).
Details
Redox score ?
82
PDB code
5urz
Structure name
crystal structure of frizzled 5 crd in complex with bog
Structure deposition date
2017-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
41
Residue number B
87
Peptide name
Frizzled-5
Ligandability
Cysteine 41 of Frizzled-5
Cysteine 87 of Frizzled-5
6ww2 R 277 R 280
A redox-regulated disulphide may form within Frizzled-5 between cysteines 277 and 280. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6ww2
Structure name
structure of human frizzled5 by fiducial-assisted cryo-em
Structure deposition date
2020-05-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
62
Peptide accession
Q13467
Residue number A
277
Residue number B
280
Peptide name
Frizzled-5
Ligandability
Cysteine 277 of Frizzled-5
Cysteine 280 of Frizzled-5
6ww2 R 222 R 315
A redox-regulated disulphide may form within Frizzled-5 between cysteines 222 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6ww2
Structure name
structure of human frizzled5 by fiducial-assisted cryo-em
Structure deposition date
2020-05-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13467
Residue number A
222
Residue number B
315
Peptide name
Frizzled-5
Ligandability
Cysteine 222 of Frizzled-5
Cysteine 315 of Frizzled-5
6ww2 R 246 R 510
A redox-regulated disulphide may form within Frizzled-5 between cysteines 246 and 510. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6ww2
Structure name
structure of human frizzled5 by fiducial-assisted cryo-em
Structure deposition date
2020-05-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
76
Peptide accession
Q13467
Residue number A
246
Residue number B
510
Peptide name
Frizzled-5
Ligandability
Cysteine 246 of Frizzled-5
Cysteine 510 of Frizzled-5
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