Sequestosome-1
Intermolecular
Cysteine 131 and cysteine 131
Cysteine 145 and cysteine 145 L
Cysteine 131 and cysteine 145 L
Cysteine 154 and cysteine 154
Intramolecular
Cysteine 128 and cysteine 154
Cysteine 142 and cysteine 145 L
Cysteine 128 and cysteine 151
Cysteine 128 and cysteine 131
Cysteine 131 and cysteine 154
Cysteine 131 and cysteine 151
More...Cysteine 151 and cysteine 154
Cysteine 26 and cysteine 27
Cysteine 27 and cysteine 44 L
5yp7 A 131 D 131
A redox-regulated disulphide may form between two units of Sequestosome-1 at cysteines 131 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5yp7
Structure name
p62/sqstm1 zz domain
Structure deposition date
2017-11-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
14
Peptide A name
Sequestosome-1
Peptide B name
Sequestosome-1
Peptide A accession
Q13501
Peptide B accession
Q13501
Peptide A residue number
131
Peptide B residue number
131
Ligandability
5yph A 21 B 21
A redox-regulated disulphide may form between two units of Sequestosome-1 at cysteines 145 and 145 (21 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
5yph
Structure name
p62/sqstm1 zz domain with ile-peptide
Structure deposition date
2017-11-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
11
% buried
30
Peptide A name
Sequestosome-1
Peptide B name
Sequestosome-1
Peptide A accession
Q13501
Peptide B accession
Q13501
Peptide A residue number
145
Peptide B residue number
145
Ligandability
6khz B 131 C 145
A redox-regulated disulphide may form between two units of Sequestosome-1 at cysteines 131 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6khz
Structure name
p62/sqstm1 zz domain with gly-peptide
Structure deposition date
2019-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
nan
Peptide A name
Sequestosome-1
Peptide B name
Sequestosome-1
Peptide A accession
Q13501
Peptide B accession
Q13501
Peptide A residue number
131
Peptide B residue number
145
Ligandability
Cysteine 131 of Sequestosome-1
Cysteine 145 of Sequestosome-1
5yp7 A 154 D 154
A redox-regulated disulphide may form between two units of Sequestosome-1 at cysteines 154 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5yp7
Structure name
p62/sqstm1 zz domain
Structure deposition date
2017-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
29
Peptide A name
Sequestosome-1
Peptide B name
Sequestosome-1
Peptide A accession
Q13501
Peptide B accession
Q13501
Peptide A residue number
154
Peptide B residue number
154
Ligandability
6miu B 128 B 154
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 128 and 154.
Details
Redox score ?
88
PDB code
6miu
Structure name
crystal structure of p62 zz domain in complex with arg-glu peptide
Structure deposition date
2018-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
5
Peptide accession
Q13501
Residue number A
128
Residue number B
154
Peptide name
Sequestosome-1
Ligandability
Cysteine 128 of Sequestosome-1
Cysteine 154 of Sequestosome-1
6khz A 142 A 145
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 142 and 145.
Details
Redox score ?
85
PDB code
6khz
Structure name
p62/sqstm1 zz domain with gly-peptide
Structure deposition date
2019-07-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
0
Peptide accession
Q13501
Residue number A
142
Residue number B
145
Peptide name
Sequestosome-1
Ligandability
Cysteine 142 of Sequestosome-1
Cysteine 145 of Sequestosome-1
6khz D 128 D 151
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 128 and 151.
Details
Redox score ?
84
PDB code
6khz
Structure name
p62/sqstm1 zz domain with gly-peptide
Structure deposition date
2019-07-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
4
Peptide accession
Q13501
Residue number A
128
Residue number B
151
Peptide name
Sequestosome-1
Ligandability
Cysteine 128 of Sequestosome-1
Cysteine 151 of Sequestosome-1
6miu A 128 A 131
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 128 and 131.
Details
Redox score ?
82
PDB code
6miu
Structure name
crystal structure of p62 zz domain in complex with arg-glu peptide
Structure deposition date
2018-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
36
Peptide accession
Q13501
Residue number A
128
Residue number B
131
Peptide name
Sequestosome-1
Ligandability
Cysteine 128 of Sequestosome-1
Cysteine 131 of Sequestosome-1
6khz D 131 D 154
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 131 and 154.
Details
Redox score ?
77
PDB code
6khz
Structure name
p62/sqstm1 zz domain with gly-peptide
Structure deposition date
2019-07-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
0
Peptide accession
Q13501
Residue number A
131
Residue number B
154
Peptide name
Sequestosome-1
Ligandability
Cysteine 131 of Sequestosome-1
Cysteine 154 of Sequestosome-1
6miu A 131 A 151
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 131 and 151.
Details
Redox score ?
73
PDB code
6miu
Structure name
crystal structure of p62 zz domain in complex with arg-glu peptide
Structure deposition date
2018-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
42
Peptide accession
Q13501
Residue number A
131
Residue number B
151
Peptide name
Sequestosome-1
Ligandability
Cysteine 131 of Sequestosome-1
Cysteine 151 of Sequestosome-1
6khz B 151 B 154
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 151 and 154.
Details
Redox score ?
62
PDB code
6khz
Structure name
p62/sqstm1 zz domain with gly-peptide
Structure deposition date
2019-07-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
68
Peptide accession
Q13501
Residue number A
151
Residue number B
154
Peptide name
Sequestosome-1
Ligandability
Cysteine 151 of Sequestosome-1
Cysteine 154 of Sequestosome-1
4mjs J 26 J 27
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 26 and 27. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4mjs
Structure name
crystal structure of a pb1 complex
Structure deposition date
2013-09-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
10
Peptide accession
Q13501
Residue number A
26
Residue number B
27
Peptide name
Sequestosome-1
Ligandability
Cysteine 26 of Sequestosome-1
Cysteine 27 of Sequestosome-1
4mjs X 27 X 44
A redox-regulated disulphide may form within Sequestosome-1 between cysteines 27 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4mjs
Structure name
crystal structure of a pb1 complex
Structure deposition date
2013-09-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
38
Peptide accession
Q13501
Residue number A
27
Residue number B
44
Peptide name
Sequestosome-1
Ligandability
Cysteine 27 of Sequestosome-1
Cysteine 44 of Sequestosome-1
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