ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Short transient receptor potential channel 3

Intramolecular
Cysteine 267 and cysteine 269
Cysteine 267 and cysteine 272
Cysteine 269 and cysteine 272
Cysteine 211 and cysteine 269
Cysteine 211 and cysteine 272
A redox-regulated disulphide may form within Short transient receptor potential channel 3 between cysteines 267 and 269 (182 and 184 respectively in this structure).

Details

Redox score ?
88
PDB code
7dxe
Structure name
structure of trpc3 gain of function mutation r803c at 3
Structure deposition date
2021-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
27
Minimum pKa ?
7
% buried
0
Peptide accession
Q13507
Residue number A
267
Residue number B
269
Peptide name
Short transient receptor potential channel 3

Ligandability

Cysteine 267 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 3 between cysteines 267 and 272 (182 and 187 respectively in this structure).

Details

Redox score ?
80
PDB code
6cud
Structure name
structure of the human trpc3 in a lipid-occupied, closed state
Structure deposition date
2018-03-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
nan
Peptide accession
Q13507
Residue number A
267
Residue number B
272
Peptide name
Short transient receptor potential channel 3

Ligandability

Cysteine 267 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 3 between cysteines 269 and 272 (184 and 187 respectively in this structure).

Details

Redox score ?
80
PDB code
6cud
Structure name
structure of the human trpc3 in a lipid-occupied, closed state
Structure deposition date
2018-03-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
34
Minimum pKa ?
9
% buried
nan
Peptide accession
Q13507
Residue number A
269
Residue number B
272
Peptide name
Short transient receptor potential channel 3

Ligandability

Cysteine 269 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 3 between cysteines 211 and 269 (126 and 184 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7dxb
Structure name
structure of trpc3 at 2
Structure deposition date
2021-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
22
Peptide accession
Q13507
Residue number A
211
Residue number B
269
Peptide name
Short transient receptor potential channel 3

Ligandability

Cysteine 211 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 3 between cysteines 211 and 272 (126 and 187 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7dxb
Structure name
structure of trpc3 at 2
Structure deposition date
2021-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
29
Peptide accession
Q13507
Residue number A
211
Residue number B
272
Peptide name
Short transient receptor potential channel 3

Ligandability

Cysteine 211 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Short transient receptor potential channel 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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