ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Acid ceramidase

Intermolecular
Cysteine 31 and cysteine 340
Intramolecular
Cysteine 388 and cysteine 392
Cysteine 31 and cysteine 340
A redox-regulated disulphide may form between two units of Acid ceramidase at cysteines 31 and 340.

Details

Redox score ?
84
PDB code
6mhm
Structure name
crystal structure of human acid ceramidase in covalent complex with carmofur
Structure deposition date
2018-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
Acid ceramidase
Peptide B name
Acid ceramidase
Peptide A accession
Q13510
Peptide B accession
Q13510
Peptide A residue number
31
Peptide B residue number
340

Ligandability

Cysteine 31 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acid ceramidase between cysteines 388 and 392.

Details

Redox score ?
85
PDB code
5u84
Structure name
acid ceramidase (asah1, acdase) from common minke whale, cys143ala, uncleaved
Structure deposition date
2016-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A383ZFX3
Residue number A
388
Residue number B
392
Peptide name
Acid ceramidase

Ligandability

Cysteine 388 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acid ceramidase between cysteines 31 and 340.

Details

Redox score ?
83
PDB code
5u81
Structure name
acid ceramidase (asah1, acdase) from naked mole rat, cys143ala, uncleaved
Structure deposition date
2016-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0P6JG37
Residue number A
31
Residue number B
340
Peptide name
Acid ceramidase

Ligandability

Cysteine 31 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Acid ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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