ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Serine/threonine-protein kinase PRP4 homolog

Intramolecular
Cysteine 750 and cysteine 809
Cysteine 750 and cysteine 833
A redox-regulated disulphide may form within Serine/threonine-protein kinase PRP4 homolog between cysteines 750 and 809. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6pjj
Structure name
human prpf4b bound to benzothiophene inhibitor 224
Structure deposition date
2019-06-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
70
Peptide accession
Q13523
Residue number A
750
Residue number B
809
Peptide name
Serine/threonine-protein kinase PRP4 homolog

Ligandability

Cysteine 750 of Serine/threonine-protein kinase PRP4 homolog

Cysteine 809 of Serine/threonine-protein kinase PRP4 homolog

A redox-regulated disulphide may form within Serine/threonine-protein kinase PRP4 homolog between cysteines 750 and 833. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4iir
Structure name
crystal structure of amppnp-bound human prpf4b kinase domain
Structure deposition date
2012-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
Q13523
Residue number A
750
Residue number B
833
Peptide name
Serine/threonine-protein kinase PRP4 homolog

Ligandability

Cysteine 750 of Serine/threonine-protein kinase PRP4 homolog

Cysteine 833 of Serine/threonine-protein kinase PRP4 homolog

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