ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine incorporator 3

Intramolecular
Cysteine 234 and cysteine 295
Cysteine 248 and cysteine 453
Cysteine 220 and cysteine 248
A redox-regulated disulphide may form within Serine incorporator 3 between cysteines 234 and 295.

Details

Redox score ?
83
PDB code
7rug
Structure name
human serinc3-deltaicl4
Structure deposition date
2021-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
0
Peptide accession
Q13530
Residue number A
234
Residue number B
295
Peptide name
Serine incorporator 3

Ligandability

Cysteine 234 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine incorporator 3 between cysteines 248 and 453. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7ru6
Structure name
cryo-em structure of the hiv-1 restriction factor human serinc3
Structure deposition date
2021-08-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
94
Peptide accession
Q13530
Residue number A
248
Residue number B
453
Peptide name
Serine incorporator 3

Ligandability

Cysteine 248 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine incorporator 3 between cysteines 220 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7ru6
Structure name
cryo-em structure of the hiv-1 restriction factor human serinc3
Structure deposition date
2021-08-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
80
Peptide accession
Q13530
Residue number A
220
Residue number B
248
Peptide name
Serine incorporator 3

Ligandability

Cysteine 220 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Serine incorporator 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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