ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-interacting serine/threonine-protein kinase 1

Intramolecular
Cysteine 601 and cysteine 656
Cysteine 233 and cysteine 240
A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 1 between cysteines 601 and 656.

Details

Redox score ?
83
PDB code
6ac5
Structure name
crystal structure of ripk1 death domain glcnacylated by epec effector nleb
Structure deposition date
2018-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13546
Residue number A
601
Residue number B
656
Peptide name
Receptor-interacting serine/threonine-protein kinase 1

Ligandability

Cysteine 601 of Receptor-interacting serine/threonine-protein kinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 656 of Receptor-interacting serine/threonine-protein kinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 1 between cysteines 233 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4neu
Structure name
x-ray structure of receptor interacting protein 1 (rip1)kinase domain with a 1-aminoisoquinoline inhibitor
Structure deposition date
2013-10-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
34
Minimum pKa ?
8
% buried
0
Peptide accession
Q13546
Residue number A
233
Residue number B
240
Peptide name
Receptor-interacting serine/threonine-protein kinase 1

Ligandability

Cysteine 233 of Receptor-interacting serine/threonine-protein kinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Receptor-interacting serine/threonine-protein kinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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