ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium/calmodulin-dependent protein kinase type II subunit beta

Intramolecular
Cysteine 65 and cysteine 127
Cysteine 127 and cysteine 200
A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase type II subunit beta between cysteines 65 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
3bhh
Structure name
crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b)
Structure deposition date
2007-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
100
Peptide accession
Q13554
Residue number A
65
Residue number B
127
Peptide name
Calcium/calmodulin-dependent protein kinase type II subunit beta

Ligandability

Cysteine 65 of Calcium/calmodulin-dependent protein kinase type II subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Calcium/calmodulin-dependent protein kinase type II subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase type II subunit beta between cysteines 127 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
3bhh
Structure name
crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b)
Structure deposition date
2007-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
Q13554
Residue number A
127
Residue number B
200
Peptide name
Calcium/calmodulin-dependent protein kinase type II subunit beta

Ligandability

Cysteine 127 of Calcium/calmodulin-dependent protein kinase type II subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Calcium/calmodulin-dependent protein kinase type II subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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