Calcium/calmodulin-dependent protein kinase type II subunit delta

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Calcium/calmodulin-dependent protein kinase type II subunit delta at cysteines 428 and 428. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2w2c

Structure name

structure of the tetradecameric oligomerisation domain of calcium- calmodulin dependent protein kinase ii delta

Structure deposition date

2008-10-28

Thiol separation (Å)

Half-sphere exposure sum ?

103

Minimum pK_a ?

% buried

100

Peptide A name

Calcium/calmodulin-dependent protein kinase type II subunit delta

Peptide B name

Calcium/calmodulin-dependent protein kinase type II subunit delta

Peptide A accession

Q13557

Peptide B accession

Q13557

Peptide A residue number

428

Peptide B residue number

428

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase type II subunit delta between cysteines 65 and 127 (66 and 128 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6bab

Structure name

the structure of human camkii with bound inhibitor

Structure deposition date

2017-10-12

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q6PHZ2

Residue number A

Residue number B

127

Peptide name

Calcium/calmodulin-dependent protein kinase type II subunit delta

Ligandability

Cysteine 65 of Calcium/calmodulin-dependent protein kinase type II subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Calcium/calmodulin-dependent protein kinase type II subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase type II subunit delta between cysteines 127 and 200 (128 and 201 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?