NEDD8-activating enzyme E1 regulatory subunit

Intramolecular

A redox-regulated disulphide may form within NEDD8-activating enzyme E1 regulatory subunit between cysteines 460 and 483. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3dbl

Structure name

structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8's e1 (appbp1-uba3arg190wt-nedd8ala72gln)

Structure deposition date

2008-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q13564

Residue number A

460

Residue number B

483

Peptide name

NEDD8-activating enzyme E1 regulatory subunit

Ligandability

Cysteine 460 of NEDD8-activating enzyme E1 regulatory subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.