ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon regulatory factor 5

Intramolecular
Cysteine 340 and cysteine 342
Cysteine 342 and cysteine 398
A redox-regulated disulphide may form within Interferon regulatory factor 5 between cysteines 340 and 342 (330 and 332 respectively in this structure).

Details

Redox score ?
60
PDB code
3dsh
Structure name
crystal structure of dimeric interferon regulatory factor 5 (irf-5) transactivation domain
Structure deposition date
2008-07-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
88
Peptide accession
Q13568
Residue number A
340
Residue number B
342
Peptide name
Interferon regulatory factor 5

Ligandability

Cysteine 340 of Interferon regulatory factor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Interferon regulatory factor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon regulatory factor 5 between cysteines 342 and 398 (332 and 388 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3dsh
Structure name
crystal structure of dimeric interferon regulatory factor 5 (irf-5) transactivation domain
Structure deposition date
2008-07-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
80
Peptide accession
Q13568
Residue number A
342
Residue number B
398
Peptide name
Interferon regulatory factor 5

Ligandability

Cysteine 342 of Interferon regulatory factor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Interferon regulatory factor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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