ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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G/T mismatch-specific thymine DNA glycosylase

Intramolecular
Cysteine 233 and cysteine 276 L
A redox-regulated disulphide may form within G/T mismatch-specific thymine DNA glycosylase between cysteines 233 and 276. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3ufj
Structure name
human thymine dna glycosylase bound to substrate analog 2'-fluoro-2'- deoxyuridine
Structure deposition date
2011-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
12
% buried
100
Peptide accession
Q13569
Residue number A
233
Residue number B
276
Peptide name
G/T mismatch-specific thymine DNA glycosylase

Ligandability

Cysteine 233 of G/T mismatch-specific thymine DNA glycosylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 276 of G/T mismatch-specific thymine DNA glycosylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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