ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Inositol-tetrakisphosphate 1-kinase

Intramolecular
Cysteine 156 and cysteine 185
Cysteine 137 and cysteine 185
Cysteine 137 and cysteine 156
A redox-regulated disulphide may form within Inositol-tetrakisphosphate 1-kinase between cysteines 156 and 185.

Details

Redox score ?
63
PDB code
2qb5
Structure name
crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase (itpk1) in complex with adp and mn2+
Structure deposition date
2007-06-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13572
Residue number A
156
Residue number B
185
Peptide name
Inositol-tetrakisphosphate 1-kinase

Ligandability

Cysteine 156 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol-tetrakisphosphate 1-kinase between cysteines 137 and 185.

Details

Redox score ?
62
PDB code
2q7d
Structure name
crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase (itpk1) in complex with amppnp and mn2+
Structure deposition date
2007-06-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
48
Peptide accession
Q13572
Residue number A
137
Residue number B
185
Peptide name
Inositol-tetrakisphosphate 1-kinase

Ligandability

Cysteine 137 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol-tetrakisphosphate 1-kinase between cysteines 137 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2q7d
Structure name
crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase (itpk1) in complex with amppnp and mn2+
Structure deposition date
2007-06-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
58
Peptide accession
Q13572
Residue number A
137
Residue number B
156
Peptide name
Inositol-tetrakisphosphate 1-kinase

Ligandability

Cysteine 137 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Inositol-tetrakisphosphate 1-kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: