a tool for identifying drug-targetable redox-active disulphides

SNW domain-containing protein 1

Intermolecular

Cysteine 719 of Pre-mRNA-processing-splicing factor 8 and cysteine 250 L

A redox-regulated disulphide may form between cysteine 719 of Pre-mRNA-processing-splicing factor 8 and cysteine 250 of SNW domain-containing protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

35

PDB code

Structure name

cryo-em structure of a human post-catalytic spliceosome (p complex) at 3

Structure deposition date

2018-09-07

Thiol separation (Å)

9

Half-sphere exposure sum ?

64

Minimum pK_a ?

13

% buried

96

Peptide A name

Pre-mRNA-processing-splicing factor 8

Peptide B name

SNW domain-containing protein 1

Peptide A accession

Peptide B accession

Peptide A residue number

719

Peptide B residue number

250

Ligandability

Cysteine 719 of Pre-mRNA-processing-splicing factor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of SNW domain-containing protein 1

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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