ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Deoxyribonuclease gamma

Intramolecular
Cysteine 194 and cysteine 231
Cysteine 24 and cysteine 52
A redox-regulated disulphide may form within Deoxyribonuclease gamma between cysteines 194 and 231.

Details

Redox score ?
82
PDB code
7kiu
Structure name
structure of recombinant human dnase1l3 in complex with mg2+
Structure deposition date
2020-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13609
Residue number A
194
Residue number B
231
Peptide name
Deoxyribonuclease gamma

Ligandability

Cysteine 194 of Deoxyribonuclease gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Deoxyribonuclease gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deoxyribonuclease gamma between cysteines 24 and 52.

Details

Redox score ?
71
PDB code
7kiu
Structure name
structure of recombinant human dnase1l3 in complex with mg2+
Structure deposition date
2020-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
50
Peptide accession
Q13609
Residue number A
24
Residue number B
52
Peptide name
Deoxyribonuclease gamma

Ligandability

Cysteine 24 of Deoxyribonuclease gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Deoxyribonuclease gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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