ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cullin-1

Intramolecular
Cysteine 53 and cysteine 137
Cysteine 426 and cysteine 496
A redox-regulated disulphide may form within Cullin-1 between cysteines 53 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1ldj
Structure name
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex
Structure deposition date
2002-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
75
Peptide accession
Q13616
Residue number A
53
Residue number B
137
Peptide name
Cullin-1

Ligandability

Cysteine 53 of Cullin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Cullin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cullin-1 between cysteines 426 and 496 (425 and 495 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
1u6g
Structure name
crystal structure of the cand1-cul1-roc1 complex
Structure deposition date
2004-07-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
100
Peptide accession
Q13616
Residue number A
426
Residue number B
496
Peptide name
Cullin-1

Ligandability

Cysteine 426 of Cullin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 496 of Cullin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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