Cullin-2

Intramolecular

A redox-regulated disulphide may form within Cullin-2 between cysteines 250 and 266. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5n4w

Structure name

crystal structure of the cul2-rbx1-elobc-vhl ubiquitin ligase complex

Structure deposition date

2017-02-11

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q13617

Residue number A

250

Residue number B

266

Peptide name

Cullin-2

Ligandability

Cysteine 250 of Cullin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Cullin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cullin-2 between cysteines 232 and 282. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5n4w

Structure name

crystal structure of the cul2-rbx1-elobc-vhl ubiquitin ligase complex

Structure deposition date

2017-02-11

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q13617

Residue number A

232

Residue number B

282

Peptide name

Cullin-2

Ligandability

Cysteine 232 of Cullin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Cullin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cullin-2 between cysteines 385 and 465. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?