ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cullin-3

Intramolecular
Cysteine 187 and cysteine 251
Cysteine 314 and cysteine 316
A redox-regulated disulphide may form within Cullin-3 between cysteines 187 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4eoz
Structure name
crystal structure of the spop btb domain complexed with the cul3 n- terminal domain
Structure deposition date
2012-04-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
76
Peptide accession
Q13618
Residue number A
187
Residue number B
251
Peptide name
Cullin-3

Ligandability

Cysteine 187 of Cullin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Cullin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cullin-3 between cysteines 314 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5nlb
Structure name
crystal structure of human cul3 n-terminal domain bound to keap1 btb and 3-box
Structure deposition date
2017-04-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
59
Peptide accession
Q13618
Residue number A
314
Residue number B
316
Peptide name
Cullin-3

Ligandability

Cysteine 314 of Cullin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Cullin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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