ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Intramolecular
Cysteine 286 and cysteine 312
A redox-regulated disulphide may form within Dual specificity tyrosine-phosphorylation-regulated kinase 1A between cysteines 286 and 312.

Details

Redox score ?
75
PDB code
5a4l
Structure name
dyrk1a in complex with fluoro benzothiazole fragment
Structure deposition date
2015-06-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
98
Peptide accession
Q13627
Residue number A
286
Residue number B
312
Peptide name
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligandability

Cysteine 286 of Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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