ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDP-L-fucose synthase

Intramolecular
Cysteine 112 and cysteine 116 L
A redox-regulated disulphide may form within GDP-L-fucose synthase between cysteines 112 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4bl5
Structure name
crystal structure of human gdp-l-fucose synthase with bound nadp and product gdp-l-fucose
Structure deposition date
2013-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
93
Minimum pKa ?
9
% buried
100
Peptide accession
Q13630
Residue number A
112
Residue number B
116
Peptide name
GDP-L-fucose synthase

Ligandability

Cysteine 112 of GDP-L-fucose synthase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 116 of GDP-L-fucose synthase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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