ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Trophoblast glycoprotein

Intramolecular
Cysteine 300 and cysteine 344
Cysteine 62 and cysteine 68
Cysteine 66 and cysteine 77
Cysteine 298 and cysteine 323
Cysteine 62 and cysteine 66
Cysteine 66 and cysteine 68
Cysteine 68 and cysteine 77
Cysteine 62 and cysteine 77
A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 300 and 344.

Details

Redox score ?
88
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
300
Residue number B
344
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 300 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 62 and 68.

Details

Redox score ?
88
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
62
Residue number B
68
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 62 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 66 and 77.

Details

Redox score ?
85
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
66
Residue number B
77
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 66 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 298 and 323.

Details

Redox score ?
84
PDB code
4cnm
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
298
Residue number B
323
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 298 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 62 and 66.

Details

Redox score ?
70
PDB code
4cnm
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
62
Residue number B
66
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 62 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 66 and 68.

Details

Redox score ?
68
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
66
Residue number B
68
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 66 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 68 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
68
Residue number B
77
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 68 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Trophoblast glycoprotein between cysteines 62 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4cnc
Structure name
crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein)
Structure deposition date
2014-01-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13641
Residue number A
62
Residue number B
77
Peptide name
Trophoblast glycoprotein

Ligandability

Cysteine 62 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Trophoblast glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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