ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-10 receptor subunit alpha

Intramolecular
Cysteine 202 and cysteine 223
Cysteine 56 and cysteine 75
A redox-regulated disulphide may form within Interleukin-10 receptor subunit alpha between cysteines 202 and 223 (181 and 202 respectively in this structure).

Details

Redox score ?
82
PDB code
1lqs
Structure name
crystal structure of human cytomegalovirus il-10 bound to soluble human il-10r1
Structure deposition date
2002-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13651
Residue number A
202
Residue number B
223
Peptide name
Interleukin-10 receptor subunit alpha

Ligandability

Cysteine 202 of Interleukin-10 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Interleukin-10 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-10 receptor subunit alpha between cysteines 56 and 75 (35 and 54 respectively in this structure).

Details

Redox score ?
81
PDB code
1lqs
Structure name
crystal structure of human cytomegalovirus il-10 bound to soluble human il-10r1
Structure deposition date
2002-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13651
Residue number A
56
Residue number B
75
Peptide name
Interleukin-10 receptor subunit alpha

Ligandability

Cysteine 56 of Interleukin-10 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Interleukin-10 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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